Isocitrate dehydrogenase (IDH), a key enzyme in the tricarboxylic acid cycle, plays an important role in cellular energy metabolism.When the IDH gene is mutated, the enzyme activity is altered, resulting in an accumulation of a large amount of the tumor metabolite 2-hydroxyglutaric acid (2-HG), causing severe epigenetic deregulation Apple Cider Vin
Nowadays, intelligent systems are used as innovative tools in different environmental issues.However, the prediction of short-term waste, unlike the long-term scale, is less developed due to more uncertainties and the difficulty in determining measurable independent parameters.In this study, two types of artificial neural networks (MLP and RBF) and
Leptin is a small polypeptide codified by the Obese Gene (OB), deeply related with the body fat mass and energetic balance.Due to its diverse biological effects and downstream signal transducers, multiple classifications have been attributed to leptin, as hormone, cytokine, adypokine, growth factor, and developmental factor, among others.This scena
Neurons rely on action potentials, or spikes, to encode information.But spikes can encode different stimulus features in different neurons.We show here through simulations and experiments how neurons encode the integral or derivative of their input based on the distinct tuning properties conferred upon them by subthreshold currents.Slow-activating